Silicon is absorbed from the diet as orthosilicic acid and concentrations in plasma are 5-20 microM. It will be apparent that all kinds of diluents can be used in order to obtain a preparation for biological application. Neutralization is subsequently carried out to a pH of 2.7-3.0. Flavourings can be added if desired, for instance by dilution (1:30) in a 0.01 M citrate buffer (pH 3.5-3.8) and by adding a flavouring (raspberry and the like). Water glass (sodium ortho silicate) is the usual source of ortho silicic acid, which however hydrolyses after oral administration to mammals and forms insoluble and non-absorbable gels through polycondensation. of 2-methoxyethanol over a period of 40 minutes the feed was shut off, the development of hydrogen gas ending within a few minutes. The toxicity decreased markedly as the solution aged, to the point that after the solution turned to a gel it had no effects other than mechanical ones. This application is a 371 of PCT/NL95/00054, The bioavailability of silicon depends on the solubility or speciation of the compound concerned (Van Dyck et al., 1999). One can also use ferrosilicon or iron silicide as the silicon-containing component. Another or additional type of stabilizing agent is an amino acid, such as proline and serine. Subcutaneous injections of orthosilicic acid solutions (around 1%) in mice were found to cause local inflammation and edema. Privacy Policy The first is obtained by a precipitation process and the second is presented as rock crystal. The process provides good volume-time yields principally in the production of lower alkyl orthosilicic acid tetraalkyl esters. The in vitro effects of orthosilicic acid (0-50 microM) on collagen type 1 s … Therefore, the process can be conducted using alcoholate in solid form especially where a greater amount of silicic acid ester and alkali alcoholate be present. The pH of this preparation lies within the range 1-3. Neutralization can take place to a pH smaller than 4, in particular smaller than 3, in general to a pH lying in the range of 1-3, whereby any polycondensation of ortho silicic acid is substantially avoided. It became particularly desirable to provide such a process which could be carried out in one step. There is no recommended dietary allowance (RDA) for silicon. After the reaction chamber was flooded with nitrogen, the mixture was heated with stirring to about 200° C., and 2-butoxyethanol was slowly fed in until the sodium had reacted away. It is known to prepare orthosilicic acid tetraalkylesters by the reaction of silicon, iron silicide or ferrosilicon with alcohol in the presence of the corresponding alcoholate which process is carried out in the presence of 70 to 99 weight percent of the corresponding orthosilicic acid tetraalkyl ester. The alkali alkoxyalcoholate is preferably produced by the addition of alkali metal to the reaction mixture, consisting of the end product, the ether alcohol involved, and metallic silicon. The stabilization using a stabilizing agent preferably takes place with stabilizing agents containing a nitrogen atom with a free electron pair which forms a complex with the silanol groups of the ortho silicic acid. The ester that forms will then, however, be contaminated by compounds not further defined, which are caused by the impurities in the starting material. After removal of the air from the reaction vessel by means of dry nitrogen, the vessel was heated with stirring at 150° C. After the addition of about 50 ml. Usually recommended is a solution containing a stabilizing agent in which no hydrolysis can take place until after the addition of a hydrolyzing agent, such as water. After termination of the alcohol feed, the evolution of H2 also terminated a few minutes later. Let's talk silica. A purification over active carbon is then performed, followed by filtering off the formed precipitate and the active carbon. 1,793,222. Alt… If sugar/maltose is used as solid carrier, tablets and gels can be formed therefrom. Ultimately, insoluble silicates are formed. Under a vacuum of 0.1 Torr, 1085 g of orthosilicic acid tetra-2-methoxyethyl ester was obtained at 145° C. in a purity of 99.5%. The speed of the reaction depends on the amount of ether alcohol charged to the reaction mixture, and therefore the process can be precisely controlled by the rate of feed of the reacting ether alcohol. With respect to the amount of alcohol used and the amount of hydrogen formed, the reaction corresponded to a volume-time yield of about 750 grams per liter per hour. THE HYDROLYSIS OF ETHYL ORTHOSILICATE AND PREPARATION OF SILICIC ACID GELS FROM IT Introduction Ethyl orthosilicate, (C2H50)4Si,, the ester of orthosilicic acid and ethyl alcohol, is a colorless liquid boiling at 165° C. It can be hydrolyzed to produce what is known as a hydrated silica sol or A process for preparing an orthosilicic acid tetraester of a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms which comprises contacting silicon, iron silicide or ferrosilicon with a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms in the aliphatic chain in the presence of the corresponding orthosilicic acid tetraalkoxy alkyl ether at a temperature between 125 and 250° C. Dynamit Nobel Aktiengesellschaft (Troisdorf, DE), Click for automatic bibliography Orthosilic Acid (OSA) According to a 2016 article that expounded on the use of silicon for skin and hair health, orthosilicic acid (OSA) is believed to have the highest bioavailability. The cream eventually contains 0.01-0.05% by weight silicon as ortho silicic acid. Click for automatic bibliography Create . Tetrahydroxysilane. If choline is used as stabilizing agent it can be converted to choline hydrochloride using dry hydrochloric acid. If prior to the evaporation of the reaction product the solids (unreacted silicon, alcoholates etc.) of 2-ethoxyethanol was fed in over a 30 minute period, while at the same time approximately 130 liters of H2 were formed. Choline has been found very suitable, which is further recommended in that it provides the option of the stabilizing agent also forming the solution for the ortho silicic acid, and an inert solvent can therefore be omitted. A first aspect of the present invention therefore relates to a preparation comprising ortho silicic acid which is stabilized with a stabilizing agent and is substantially free of organic silicon compounds. The present invention is based on the insight that if ortho silicic acid is formed in the presence of a stabilizing agent, polycondensation is inhibited and even avoided and, furthermore organic silicon compounds substantially do not occur. generation, Gelation stabilized water-soluble silicates, <- Previous Patent (Skin treatment compo...). problems with connective tissues, arteriosclerosis, bone and tendon problems, gynaecology (fibroids, polycystic adenopathy); and. Under the reaction conditions of the invention, small percentages of the alcoholate will always be in solution, since they are very easily soluble in the ether alcohols, but less soluble in the silicic acid esters. Silicic acid (H4SiO4) Silicon tetrahydroxide. 4.8 out of 5 stars 9. However, when the alkyl radical of the ester grouping becomes long the volume-time yield obtained by the process becomes considerably poor. The choline hydrochloride is treated with dry hydrochloric acid. Serine enhances uptake in the stomach and gives additional stability. We also investigated whether orthosilicic acid promotes the urinary excretion of endogenous Al. A usage of 0.5 ml of a 2% Si-solution per day for three weeks caused a fungal infection to disappear (3 patients), where treatment with ketonazols did not render any improvement. The second group includes, for example, methyldiglycol, ethyldiglycol and butyldiglycol. If it is desired to remove the ester continuously, the entire reaction may also be performed in vacuo. The reaction mixture becomes warmer due to the exothermic production of heat by the reaction. The catalytic action of the alcoholate takes place only in solution. This invention is particularly directed to a process for the production of such orthosilicic acid tetraalkoxyalkyl esters which can be carried out at an exceptionally high volume-time yield, such as a volume-time yield equal to or better than the volume-time yields obtained in the preparation of orthosilicic acid tetraalkyl esters from simple alcohols. If for instance an edible acid, such as malic acid, is added a preparation results which is very suitable for administering to horses. Organic silicon compounds such as alcohol esters, such as ethyl ortho silicate and glycol ortho silicate, cannot be used in biological systems because of the poor solubility and the low resistance to hydrolysis, but above all because of the unacceptable toxicity. Background: Silicon (Si) is a beneficial element that has been proven to influence plant responses including growth, development and metabolism in a hormetic manner. The reaction is performed preferably under normal pressure. However, since in a number of applications of orthisilicic acid tetraalkoxyalkyl esters the purity of the product is of secondary importance (e.g., in the case of binding agents for heavily pigmented paints), one can advantageously use ferrosilicon or iron silicide. A third aspect of the present invention relates to a biological preparation containing a preparation according to claims 1-7, and/or a preparation prepared according to claims 8-13, and a pharmacologically acceptable diluent. The reaction is catalyzed by small amounts of the corresponding ether alcoholate. At a reaction temperature of 200° to 210° C., a total of 1090 g of 2-butoxyethanol was fed in over a period of 30 minutes and approximately 100 liters of H2 were formed. After the feed was shut off, the formation of H2 also ended within a few minutes. Simultaneously with the addition of the inorganic silicon compound, or following the addition of the hydrolyzing agent, the hydrolysis of the inorganic silicon compound to ortho silicic acid takes place. In its crystalline state, it is not dissolved by any oxacids. It was expected that the formation of any tetraalkoxyalkyl ether of orthosilicic acid would be obtained quite slowly. When researchers have studied osteoporosis in women, they found that eating a diet that includes 40 milligrams of silicon was linked with stronger bones than lower doses. The grain size is therefore to be under 50 microns, insofar as possible. FAB/MS with glycerol as liquid matrix provides a spectrum with a molecular cation at M/Z 104 (C+) and an MC+ adduction at M/Z243/245, typical for chloride isotropy. In the latter case it is recommendable to carry the end product in a secondary circuit. The reaction, however, will also take place with smaller amounts of alcoholate. It has, therefore, been expected that the preparation of an orthosilicic acid tetraalkoxyalkyl ester from silicon, ferrosilicon or iron silicide using an ether alcohol would proceed quite poorly owing to the inability of the silicon to be adequately wetted by the ether alcohol. After the distillation of 1 kg. Other monoalkyl ether alcohols which can be used to form the corresponding ester are: The process of the invention is preferably performed by suspending or dissolving all of the silicon and the amount of alkali metal, preferably sodium, that is required for the formation of the ether alcoholate, in a vessel containing the desired orthosilicic acid tetraalkoxyalkyl ester. Experiments on the preparation of sols and nanopowders of SiO2 based on hydrothermal solutions are performed. & Terms of Use. Journal of Colloid and Interface Science 1973, 42 (3) , 503-515. `Gmelins Handbuch der Anorganischen Chemie Silicium Part B`, 1959 Verlag Chemie GmbH. This liquid is suitable for oral and cutaneous administering. Thereafter, the corresponding alcohol corresponding to the alkoxyalkyl ester, is introduced into the reaction mixture. A second aspect of the present invention relates to a method for preparing a preparation as according to claims 1-7, which comprises of: i) providing a solution containing a stabilizing agent; ii) dissolving an inorganic silicon compound in the solution containing the stabilizing agent; and. However, a corresponding amount of the ether alcoholate may be added to the mixture in solid form or in the form of a solution in the corresponding ether alcohol. If desired, the content of hydrolyzing agent, particularly water, can be reduced by removing the hydrolyzing agent, for instance through distillation, whereby a constant viscosity is achieved if use is made of choline as the stabilizer. The process is particularly desirably carried out by including in the reaction mixture an alkali metal alcoholate corresponding to the ether alcohol to be introduced into the reaction mixture. The petitioner also provided microbiological specifications. & Terms of Use. As other monomeric silicon species, Then achieved is that no organic silicon compounds are created which have an inherent toxicity, are absorbed in the stomach and enter the blood circulation. and 9 g of sodium. Silicon is an essential trace element for plants, animals and humans. At a vacuum of 1 Torr and a temperature of 200° to 210° C., 1142 g of orthosilicic acid tetra-2-butoxyethyl ester was distilled out with a purity of 97.5%. Supersmart - Orthosilicic Acid - Form of Silicon Found in Seawater - Bone & Joint Supplement - Minerals for Healthy Skin, Hair & Nails | Non-GMO & Gluten Free - 30 ml. A two-liter glass vessel with stirrer, equipped with an insulated still, an infeed connection and a device for measuring the temperature in the liquid (thermocouple) was charged with 500 g of orthosilicic acid-2-methoxyethyl ester, which had previously been obtained by transesterification of orthosilicic acid tetramethyl ester with 2-methoxyethanol, plus 250 g of silicon (98% Si, 10μ diam.) The biological preparation according to the invention is can be used for: chronic infections with destruction of the mucous membranes: forms of sinusitis and ulcers. Orthosilicic Acid 101. It is also known that the surface of light metals is passivated when contacted with an ether alcohol. Examples of the first-named group of compounds are 2-methoxyethanol, 2-ethoxyethanol and 2-propoxyethanol. For ease in understanding the amount of reactants employed there is set forth below a table showing the broad and preferred ranges for the preparation of the tetraalkoxyalkyl esters it being understood that temperature considerations are important in the subject process in obtaining the desired high volume-time yields. This may be the case, for example, if ferrosilicon or silicon alloys are used as metallic starting components and it is not desired to have as impurities in the orthosilicic acid tetraalkoxyalkyl ester the byproducts which form when these starting products are used. © 2004-2021 FreePatentsOnline.com. Shortly before solidifying, the preparation A and perfume (4 drops) are added. It is of great importance herein that the stabilizing agent only forms a complex and does not enter into a reaction, particularly an esterifying reaction, with the ortho silicic acid. generation, METHOD OF PREPARING ORTHOSILICIC ACID TETRAALKYL ESTERS, <- Previous Patent (Process for producin...). The organic silicon preparation subject of this opinion is an aqueous solution of MMST at 4.1 mM, corresponding to 115 mg Si/L. Silicon deficiency in animals leads to bone defects. 2021-02-13. It is a conjugate acid of a trihydrogensilicate(1-). Privacy Policy Orthosilicic acid. This alkali metal ether alcoholate can be formed in situ by merely introducing into the reaction vessel, before charging the same with ether alcohol, the alkali metal itself. Scientists know it as silicon dioxide and many of us who've heard of silicon can relate because it's simply an oxide of silicon. It is often referred to as “soluble silica” because Orthosilicic Acid is a dietary form of silicon (a mineral that is involved in the creation of collagen and bones).. In this liquid stabilizing agent can be incorporated the inorganic silicon compound, such as a silicon halogenide, particularly silicon tetrachloride. The more carbon atoms the alkoxyalkyl ester has, the higher will be the preferred reaction temperature. After forming a complex the ortho silicic acid-comprising solution can if desired be partially neutralized by adding a base, such as a lye, particularly sodium hydroxide. 6 mM (Epstein, 1994) but, to our knowledge, there has been no evidence of the occurrence of biosilicification reactions in the soil. Silicic acid is a silicon oxoacid. Moreover, the process does not provide the desired high volumne-time yields such as are obtained in the preparation of orthosilicic acid tetra (lower alkyl) esters. A fat phase containing Imwitor 960 (Huls) 7%, Miglyol 812 10%, Softigon 701 (Huls) 2%, Marlowet TA 25 (Huls) 2%, Lanette N (Henkel) 4%, Isopropylmyristate 3%, a water phase containing Inositol 0.2%, Gluconate buffer 0.05 M, pH 3.8 ad 100, Glycerol 10% and the preparation A, as well as a perfume. A very acceptable preparation contains 3-5% by weight of silicon, 70s by weight of choline hydrochloride and the rest water. The silicic acid formed in situ is subsequently stabilized by forming a complex with the stabilizing agent. In a watery environment silicon is initially present as ortho silicic acid which is quickly converted by polycondensation to polysilicic acid, which transposes into a colloidal solution and gels. Orthosilicic Acid Review . At a vacuum of 0.1 Torr and a temperature of 158° C., 1280 g of orthosilicic acid tetra-2-ethoxyethyl ester was drawn off having a purity of 98.4%. It is known in this reaction to utilize silicon of specific grain sizes as these grain sizes are known to effect the speed of formation of the ester. In a clinical study at the University of Antwerp, several leading silicon supplements were tested on volunteers for a week After distillation under vacuum a preparation is obtained which contains 3% by weight of silicon, 70% by weight choline hydrochloride and the rest water. 250 g of silicon (98% Si, 10μ), 6 g of sodium and 500 g of orthosilicic acid-2-butoxyethanol previously obtained by the transesterification of orthosilicic acid tetramethyl ester with 2-butoxyethanol, were placed in the same apparatus as in Example 1. Minimum, median uptake of Si from the ingested dose was 50.3% (range: 21.9-74.7%, n … © 2004-2021 FreePatentsOnline.com. orthosilicic acid. of 2-methoxyethanol, a slight yielding of H2 occured at first, due to the reaction of the metallic sodium; then, as the addition of 2-methoxyethanol continued, the H2 development increased to 200 liters per hour. ), 8 g of sodium, and 500 g of orthosilicic acid-2-ethoxyethanol previously obtained from the transesterification of orthosilicic acid tetramethyl ester with 2-ethoxyethanol were charged into the same apparatus as in Example 1. The invention relates to a process for the preparation of a high-purity, thermally stable catalyst carrier based on aluminosilicate with 0.5 to 50% by weight SiO 2 by mixing an aluminum compound with a silicic acid compound in an aqueous medium, and subsequently drying or calcining the product obtained. silicon, iron silicide or ferrosilicon 1 to 80. monoalkyl ether of aliphatic glycol 1 to 30. All rights reserved. For the achievement of the good volume-time yields it is important to stay within the temperature limits of the invention. Percent by Weight of Reactants Component Broad Preferred. The process can also be performed by adding silicon and ether alcohol separately at the same time to a mixture of the desired ester and the alkali metal, the silicon being added, as a further variant, in the form of a suspension in the desired end product. & Terms of Use. The temperature limits stated therefore apply to normal pressure. Silicon hydrochloride (1 mol per mol) is added to the formed choline solution at a temperature which is kept below 40° C. For hydrolysis, water (ice/ice water) is added to the solution while cooling, wherein the temperature is held within the range of -20° C. to -30° C. The solution containing the ortho silicic acid is subsequently neutralized by adding sodium hydroxide wherein cooling takes place to a temperature below 0° C. The pH neutralization amounts to about 1.3. 1. Furthermore, orthosilicic acid and its small condensation compounds, such as its dimer (disilicic acid), linear and cyclic trimers (trisiloxanes), and tetramers (tetrasiloxanes) (Fig. A silicon-comprising cream is prepared as follows. Preparations then result with a silicon content generally of 1% by weight, preferably of about 4% by weight, such as 8% by weight. This mixture can be pressed to pellets which are administered to cattle. fr Composition renfermant de l'acide ortho-silicique stabilise, et composition biologique. Orthosilicic acid is a soluble form of silica present in mineral water. With respect to the hydrogen that was formed, the reaction corresponded to a volume-time yield of approximately 1145 g/liter/hour. There therefore exists a need for a silicon-comprising preparation not possessing the above stated drawbacks, because silicon has a positive biological effect on nails, hair, skin, teeth, collagen, connective tissue, bones, encourages cell generation, stimulates the immune system against infections and toxins and inhibits degenerative (ageing)-processes. This process is complicated owing to the fact that a two-step process must be performed. are separated from the reaction mixture, by filtration or centrifugation, for example, esters of greater purity are obtained upon distillation. 2004-09-16. A method for the preparation of a bioavailable silicic acid including extrudate, comprising: forming stabilized silicic acid, by hydrolysing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound consisting essentially of … & Terms of Use. The biological preparation contains 3% by weight silicon in the form of ortho silicic acid, 70% by weight choline hydrochloride, the rest water and a pH of 2.7-3.0. the growth of children: children with recurrent infections with overload of the lymphatic system. At 210° C., a total of 970 g of diethylene glycol monoethyl ether was added over a period of 40 minutes, 80 liters of H2 being formed. Quaternary ammonium compounds are preferably used, for instance tetra-alkyl compounds, wherein each alkyl group contains for instance 1-5 carbon atoms, in particular methyl and ethyl groups. When the ether alcohol feed is interrupted, the reaction soon ends as the ether alcohol still in the reactor is consumed. 250 g of silicon (98% Si, 10μ diam. When the ether alcohol is introduced into the reaction vessel containing the corresponding orthosilicic acid tetraalkoxyalkyl ester, silicon, iron silicide or ferrosilicon, an alkali metal, the corresponding alkali metal ether alcoholate is formed. Bioavailability is precisely what makes it so much more valuable than any other silicon form. Silicade immediately after preparation 108 OSA ppm (orthosilicic acid) Silicade after 1 week 124 OSA ppm Fiji water has 124 OSA ppm This will take 15 minutes to prepare. Into such vessel there is also introduced silicon, iron silicide or ferrosilicon. In the preparation of orthosilicic acid tetraalkoxyalkyl esters having a low ester grouping, such as for example the methoxy ethyl or ethoxy ethyl ester, it is preferable to operate in the lower part of the above-stated temperature range. The procedure was similar to that of Example 2 except that the reaction was performed at 120° C. The volume-time yield dropped to 1/10 of that of Example 2. If desired, a further purification of the preparation can take place, for instance through absorption of contaminants on active carbon, optionally followed by filtration. The physicochemical characteristics of the sols and nanopowders of SiO2 are determined using a set of methods. The process can also be conducted under pressure say 1 to 10 atmospheres. 424/724, 514/63, 514/970. Through use of a glucuronic acid buffer a preparation on a cream basis can be formed wherein the pH is less than 4, which creams are suitable for local cutaneous application. It, therefore, became desirable to provide a process for the preparation of such tetraalkoxyalkyl esters of orthosilicic acid whereby the desired ester could be obtained in a high volume-time yield. Contents. ChEBI. Privacy Policy In the same way as carbonic acid for compounds comprising carbon, ortho silicic acid is the most important metabolite for organic silicon compounds. At 185° C., a total of 1 kg. Orthosilicic acid [Si(OH)4]; monomeric silicic acid] is the simplest acid and the main chemical species of silicon soluble in water (Carlisle, 1997). The upper temperature limit of 225° C. may not be exceeded in the preparation of pure products (purity greater than 95%), because then the silicic acid ester will be contaminated by by-product formation. Starting point for the preparation of the ortho silicic acid-comprising preparation is a solution containing the stabilizing agent, wherein an inert solvent can be used. The mixture was heated to approximately 150° C. with stirring, after the reaction chamber was flooded with nitrogen, and 2-ethoxyethanol was fed into it in accordance with the amount of hydrogen evolved. The reaction takes place at a temperature between 125° and 250° C., preferably 140° to 225° C. The reaction is very rapid under these conditions so that the volume-time yields are at least equal to and in many instances greater than the volume-time yields obtained for the corresponding preparation of orthosilicic acid tetramethyl esters as described in West German Pat. In order to achieve a result, processes of polycondensation of orthosilicic acid, ultrafiltration membrane concentration, and cryochemical vacuum sublimation are performed. Forget orthosilicic acid for a moment. In addition, the safety of these … The orthosilicic acid tetraalkoxyalkyl esters obtained by the present process are used increasingly as binding agents for zinc dust paints.
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